ACETYLSALICYLIC ACID =ASPIRIN =ASA

 



Therapetutic action


Analgesic ,antipyretic ,non steroidal anti-inflammatory (NSAID)

Platelets antiaggregant (at lowe dose)


Indicatuon

Mild pain,fever

Secondary Presentation of severe pre-eclampsia


Forms ans strengths 

300mg tablets

75mg enteric coated table


Dosage and duration

Pain and fever

Adolescent over 16 years and adults : 300 mg to 1g every 4 to 6 hours ( max. 4 g daily),for 1 to 3 days 


Prevention of pre-eclampsia

75 to 150 mg once daily from the 12th to 36th week of gestation.stop treatment 5 to 10 days before the excepted date of delivery.


Contra -indication ,adverse effect ,precations 

Don not administer to patients with allergy to asprin and NSAID ,gastrodudenal ulcer ,coagulation disorders ,haemorrage ,sever renal ,hepatic or cardiac impairments

Do not administer to childern for pain or fever (use paracetamol). Administer with caution to older patients or patients with Asthma.


Do not exceed indicated doses,particularly in older patients.


Pregnancy; pain and fever avoid contraindication from the beginning of the 6 month . Use paracetamol.

✓ prevention of pre-eclampsia: do not exceed 150mg daily

Breast feeding : avoid . Use paracetamol.

Remarks

Take during meals,preferably with a lot of water.

Do not crust enteric coated tablets

Also comes in 500mg tablets and 300mg diapersible tablets

Storage

Below 25C⁰

Do not use if tableat or syrup a strong smell of vinegar . Aslight vinegar smell is always presents.

The storage of a drug plays a role in its quality and safety, and it also benefits the patient


Mechanism of drug action of Asprin

Inhibition of Cyclooxygenase (COX): When you experience an injury or illness, your cells release a substance called arachidonic acid. The COX enzyme converts this acid into prostaglandins and thromboxanes, which cause inflammation, pain, and fever, and make platelets sticky. Aspirin works by shutting down this COX enzyme.




1. Cell Damage: The injured cell releases various signaling molecules, like phospholipids.

2. Enzyme Activation: Enzymes such as phospholipase A2 act on these phospholipids to release arachidonic acid.

3. Arachidonic Acid Metabolism: This arachidonic acid is then converted by enzymes like cyclooxygenase (COX) into prostaglandins and other mediators.

4. Inflammatory Response: These mediators, like prostaglandins, trigger inflammation, causing symptoms such as pain, swelling, and redness.

5. Healing and Repair: Over time, the body works to resolve the inflammation and repair the damaged tissue.



Type Where Found Main Function Clinical Importance
COX-1 Stomach, kidneys, platelets Protects stomach lining, maintains kidney blood flow, helps platelets in clotting Inhibited by NSAIDs → may cause stomach irritation/ulcers
COX-2 Produced at sites of injury & inflammation Causes pain, fever, and swelling Target of anti-inflammatory drugs (e.g., ibuprofen, celecoxib)
COX-3 Brain and spinal cord (CNS) Involved in pain and fever regulation Believed to be target of paracetamol (acetaminophen)

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